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Article

Reproductive and epigenetic outcomes associated with aging mouse oocytes

17 Mar 2009

Abstract excerpt

Female aging entails a decline in fertility in mammals, manifested by reduced oocyte reserves and poor oocyte quality accompanied by chromosomal anomalies and reduced litter size. In addition to compromised genetic integrity, recent studies suggest that epigenetic mechanisms may be altered in aging oocytes, with age affecting the expression of DNA methyltransferases, which catalyze the important epigenetic...

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PMID: 19293340
DOI: 10.1093/hmg/ddp127

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