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Article

The actin nucleator Spir-1 is a virus restriction factor that promotes innate immune signalling

11 Feb 2022

Abstract excerpt

Cellular proteins often have multiple and diverse functions. This is illustrated with protein Spir-1 that is an actin nucleator, but, as shown here, also functions to enhance innate immune signalling downstream of RNA sensing by RIG-I/MDA-5. In human and mouse cells lacking Spir-1, IRF3 and NF-κB-dependent gene activation is impaired, whereas Spir-1 overexpression enhanced IRF3 activation. Furthermore, the...

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PMID: 35148361
DOI: 10.1371/journal.ppat.1010277

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