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Article

Caffeine Therapy for Apnea of Prematurity: Role of the Circadian CLOCK Gene Polymorphism

25 Jan 2022

Abstract excerpt

Standard-dose caffeine citrate has been routinely prescribed for apnea of prematurity (AOP) management; however, some preterm infants respond well to the therapy while others do not. The AOP phenotype has been attributed solely to the immature control of the respiratory system consequent to preterm birth, but there are also important genetic influences. Based on our previous report, we tested the hypothesis that...

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PMID: 35145399
DOI: 10.3389/fphar.2021.724145

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