Article
ILF2 enhances the DNA cytosine deaminase activity of tumor mutator APOBEC3B in multiple myeloma cells.
Scientific reports - 10 Feb 2022
Kazuma Yasuhiro, Shirakawa Kotaro, Tashiro Yusuke, Yamazaki Hiroyuki, Nomura Ryosuke, Horisawa Yoshihito, Takeuchi Suguru, Stanford Emani, Konishi Yoshinobu, Matsui Hiroyuki, Matsumoto Tadahiko, Tanabe Fumiko, Morishita Ryo, Ito Shinji, Takaori-Kondo Akifumi
Abstract excerpt
DNA cytosine deaminase APOBEC3B (A3B) is an endogenous source of mutations in many human cancers, including multiple myeloma. A3B proteins form catalytically inactive high molecular mass (HMM) complexes in nuclei, however, the regulatory mechanisms of A3B deaminase activity in HMM complexes are still unclear. Here, we performed mass spectrometry analysis of A3B-interacting proteins from nuclear extracts of...
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