Article
A mammalian methylation array for profiling methylation levels at conserved sequences.
Nature communications - 10 Feb 2022
Arneson Adriana, Haghani Amin, Thompson Michael J, Pellegrini Matteo, Kwon Soo Bin, Vu Ha, Maciejewski Emily, Yao Mingjia, Li Caesar Z, Lu Ake T, Morselli Marco, Rubbi Liudmilla, Barnes Bret, Hansen Kasper D, Zhou Wanding, Breeze Charles E, Ernst Jason, Horvath Steve
Abstract excerpt
Infinium methylation arrays are not available for the vast majority of non-human mammals. Moreover, even if species-specific arrays were available, probe differences between them would confound cross-species comparisons. To address these challenges, we developed the mammalian methylation array, a single custom array that measures up to 36k CpGs per species that are well conserved across many mammalian species. We...
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