Article
One-step generation of heritable mitochondrial DNA multiplex-engineered rats using DddA-derived cytosine base editor.
Animal models and experimental medicine - 1 Aug 2026
Zhang Xu, Li Keru, Tan Lei, Chen Wei, Gao Shan, Liu Chenyang, Pan Shuo, He Jiayue, Liu Ning, Wan Gefan, Dong Wei, Kong Weining, Shen Bin, Qi Xiaolong, Ma Yuanwu
Abstract excerpt
BACKGROUND: Mitochondrial DNA (mtDNA) mutations are implicated in a wide range of diseases, underscoring the need to elucidate the relationship between mtDNA mutations and disease pathology. These diseases are often characterized by the presence of multiple mutations; however, research has been hampered by the lack of suitable animal models carrying multiplex mtDNA mutations. Such models cannot be produced...
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