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Article

Clinical significance of Y chromosome loss in hematologic disease

1 Jan 2000

Abstract excerpt

We have studied 215 male patients (aged 45-97 years) whose sole cytogenetic abnormality was clonal loss of the Y chromosome in metaphase cells from unstimulated cultures. The patients comprised a control group with no evidence of hematologic disease and four disease case groups: 1) myelodysplastic syndrome (MDS), refractory anemia, refractory anemia with excess blasts (RAEB), RAEB in transformation, and chronic...

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PMID: 10564581
DOI: 10.1002/(sici)1098-2264(200001)27:1<11::aid-gcc2>3.0.co;2-i

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