Article
Nickel exposure induces persistent mesenchymal phenotype in human lung epithelial cells through epigenetic activation of ZEB1.
Molecular carcinogenesis - 1 Jun 2018
Jose Cynthia C, Jagannathan Lakshmanan, Tanwar Vinay S, Zhang Xiaoru, Zang Chongzhi, Cuddapah Suresh
Abstract excerpt
Nickel (Ni) is an environmental and occupational carcinogen, and exposure to Ni is associated with lung and nasal cancers in humans. Furthermore, Ni exposure is implicated in several lung diseases including chronic inflammatory airway diseases, asthma, and fibrosis. However, the mutagenic potential of Ni is low and does not correlate with its potent toxicity and carcinogenicity. Therefore, mechanisms underlying...
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