Article
N6-methyladenosine facilitates arsenic-induced neoplastic phenotypes of human bronchial epithelial cells by promoting miR-106b-5p maturation.
Ecotoxicology and environmental safety - 15 Sept 2024
Chen Biyun, Wang Lujiao, Li Luyao, Zhou Mei, Pan Shuya, Wang Qin, Hou Yaxuan, Zhou Xue
Abstract excerpt
Arsenic is a widespread carcinogen and an important etiological factor for lung cancer. Dysregulated miRNAs have been implicated in arsenic carcinogenesis and the mechanisms of arsenic-induced dysregulated miRNAs have not been fully elucidated. N6-methyladenosine (m6A) modification is known to modulate pri-miRNA processing. However, whether m6A-mediated pri-miRNA processing is involved in arsenic carcinogenesis...
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