Article

Convergent mutations in phage virion assembly proteins enable evasion of Type I CBASS immunity

2023-05-21

Abstract excerpt

<h4>SUMMARY</h4> CBASS is an anti-phage defense system that protects bacteria from phage infection and is evolutionarily related to human cGAS-STING immunity. cGAS-STING signaling is initiated by viral DNA but the stage of phage replication which activates bacterial CBASS remains unclear. Here we define the specificity of Type I CBASS immunity using a comprehensive analysis of 975 operon-phage pairings and show t...

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Literature Corpus work: 6f969dbe-2017-57cb-bd15-344cb48294e3
DOI: 10.1101/2023.05.21.541620

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