Article
Somatic mutations in collagens are associated with a distinct tumor environment and overall survival in gastric cancer.
BMC cancer - 4 Feb 2022
Brodsky Alexander S, Khurana Jay, Guo Kevin S, Wu Elizabeth Y, Yang Dongfang, Siddique Ayesha S, Wong Ian Y, Gamsiz Uzun Ece D, Resnick Murray B
Abstract excerpt
BACKGROUND: Gastric cancer is a heterogeneous disease with poorly understood genetic and microenvironmental factors. Mutations in collagen genes are associated with genetic diseases that compromise tissue integrity, but their role in tumor progression has not been extensively reported. Aberrant collagen expression has been long associated with malignant tumor growth, invasion, chemoresistance, and patient...
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