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Article

Telomere dysfunction accurately predicts clinical outcome in chronic lymphocytic leukaemia, even in patients with early stage disease.

British journal of haematology - 1 Oct 2014

Lin Thet Thet, Norris Kevin, Heppel Nicole H, Pratt Guy, Allan James M, Allsup David J, Bailey James, Cawkwell Lynn, Hills Robert, Grimstead Julia W, Jones Rhiannon E, Britt-Compton Bethan, Fegan Chris, Baird Duncan M, Pepper Chris

Abstract excerpt

Defining the prognosis of individual cancer sufferers remains a significant clinical challenge. Here we assessed the ability of high-resolution single telomere length analysis (STELA), combined with an experimentally derived definition of telomere dysfunction, to predict the clinical outcome of patients with chronic lymphocytic leukaemia (CLL). We defined the upper telomere length threshold at which telomere...

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Share to DNA, Neoplasm
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukemia, Lymphocytic, Chronic, B-Cell

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Source

Identifiers

PMID: 24990087
DOI: 10.1111/bjh.13023

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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