Resident memory T cells in tumor-distant tissues fortify against metastasis formation

Abstract excerpt

As a critical machinery for rapid pathogen removal, resident memory T cells (T RM s) are locally generated after the initial encounter. However, their development accompanying tumorigenesis remains elusive. Using a murine breast cancer model, we show that T RM s develop in the tumor, the contralateral mammary mucosa, and the pre-metastatic lung. Single-cell RNA sequencing of T RM s reveals two phenotypically...

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