Article
Finger printing human norovirus-like particles by capillary isoelectric focusing with whole column imaging detection.
Virus research - 2 Apr 2022
Du Jialiang, Wu Gang, Cui Chunbo, Yu Chuanfei, Cui Yongfei, Guo Luyun, Liu Yueyue, Liu Yan, Wang Wenbo, Liu Chunyu, Fu Zhihao, Li Meng, Guo Sha, Yu Xiaojuan, Yang Yalan, Duan Maoqin, Xu Gangling, Wang Lan
Abstract excerpt
Owing to the limitation of in vitro culture of human noroviruses (HuNoVs), the development of HuNoV vaccines has to depend on the self-assembling virus-like particles (VLPs) with capsid protein expression. The heterogeneity of artificial VLPs exert an impact on the immunogenicity, and should be considered as one of the factors in vaccine evaluation. In this study, we biochemically finger print the HuNoV VLPs with...
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