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The neural crest is a source of mesenchymal stem cells with specialized hematopoietic stem cell niche function

25 Sept 2014

Abstract excerpt

Mesenchymal stem cells (MSCs) and osteolineage cells contribute to the hematopoietic stem cell (HSC) niche in the bone marrow of long bones. However, their developmental relationships remain unclear. In this study, we demonstrate that different MSC populations in the developing marrow of long bones have distinct functions. Proliferative mesoderm-derived nestin(-) MSCs participate in fetal skeletogenesis and lose...

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PMID: 25255216
DOI: 10.7554/elife.03696

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