Article
Clonal Expansion of Stem/Progenitor Cells in Cancer, Fibrotic Diseases, and Atherosclerosis, and CD47 Protection of Pathogenic Cells.
Annual review of medicine - 27 Jan 2022
Majeti R, Jamieson C, Pang W W, Jaiswal S, Leeper N J, Wernig G, Weissman I L
Abstract excerpt
We proposed and demonstrated that myelogenous leukemia has a preleukemic phase. In the premalignant phase, normal hematopoietic stem cells (HSCs) gradually accumulate mutations leading to HSC clonal expansion, resulting in the emergence of leukemic stem cells (LSCs). Here, we show that preleukemic HSCs are the basis of clonal hematopoiesis, as well as late-onset blood diseases (chronic-phase chronic myeloid...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.