Article
Low CCR5 expression protects HIV-specific CD4+ T cells of elite controllers from viral entry.
Nature communications - 26 Jan 2022
Claireaux Mathieu, Robinot Rémy, Kervevan Jérôme, Patgaonkar Mandar, Staropoli Isabelle, Brelot Anne, Nouël Alexandre, Gellenoncourt Stacy, Tang Xian, Héry Mélanie, Volant Stevenn, Perthame Emeline, Avettand-Fenoël Véronique, Buchrieser Julian, Cokelaer Thomas, Bouchier Christiane, Ma Laurence, Boufassa Faroudy, Hendou Samia, Libri Valentina, Hasan Milena, Zucman David, de Truchis Pierre, Schwartz Olivier, Lambotte Olivier, Chakrabarti Lisa A
Abstract excerpt
HIV elite controllers maintain a population of CD4 + T cells endowed with high avidity for Gag antigens and potent effector functions. How these HIV-specific cells avoid infection and depletion upon encounter with the virus remains incompletely understood. Ex vivo characterization of single Gag-specific CD4 + T cells reveals an advanced Th1 differentiation pattern in controllers, except for the CCR5 marker, which...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.