Prognostic impact of miR-34b/c DNA methylation, gene expression, and promoter polymorphism in HPV-negative oral squamous cell carcinomas.

doi:10.1038/s41598-022-05399-1

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Article

Prognostic impact of miR-34b/c DNA methylation, gene expression, and promoter polymorphism in HPV-negative oral squamous cell carcinomas.

Scientific reports - 25 Jan 2022

Supic Gordana, Stefik Debora, Ivkovic Nemanja, Sami Ahmad, Zeljic Katarina, Jovic Sasa, Kozomara Ruzica, Vojvodic Danilo, Stosic Srboljub

Abstract excerpt

Micro RNAs (miRNAs) have a key role in gene expression regulation in cancer. The aim of the current study is to evaluate the prognostic value of miR-34b/c promoter hypermethylation, gene expression, and polymorphism in HPV-negative oral squamous cell carcinomas (OSCC). MiR-34b/c promoter hypermethylation and pre-miR-34b/c polymorphism rs4938723 were evaluated in tumor tissues of 148 patients, and miR-34b...

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PMID: 35079080
DOI: 10.1038/s41598-022-05399-1
PMCID: PMC8789922

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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