Article
Combined analysis of pri-miR-34b/c rs4938723 and TP53 Arg72Pro with cervical cancer risk.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 May 2016
Yuan Fang, Sun Ruifen, Chen Peng, Liang Yundan, Ni Shanshan, Quan Yi, Huang Juan, Zhang Lin, Gao Linbo
Abstract excerpt
miR-34 family members can form a p53-miR-34 positive feedback loop and induce apoptosis, DNA repair, angiogenesis, and cell cycle arrest. We conducted a case-control study to examine whether two polymorphisms (i.e., rs4938723 in the promoter of pri-miR-34b/c and TP53 Arg72Pro) were linked to the carcinogenesis of cervical cancer among Chinese Han women. Genotypes of the two polymorphisms in 328 cervical cancer...
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