Disruption of MeCP2-TCF20 complex underlies distinct neurodevelopmental disorders.

doi:10.1073/pnas.2119078119

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Article

Disruption of MeCP2-TCF20 complex underlies distinct neurodevelopmental disorders.

Proceedings of the National Academy of Sciences of the United States of America - 25 Jan 2022

Zhou Jian, Hamdan Hamdan, Yalamanchili Hari Krishna, Pang Kaifang, Pohodich Amy E, Lopez Joanna, Shao Yingyao, Oses-Prieto Juan A, Li Lifang, Kim Wonho, Durham Mark A, Bajikar Sameer S, Palmer Donna J, Ng Philip, Thompson Michelle L, Bebin E Martina, Müller Amelie J, Kuechler Alma, Kampmeier Antje, Haack Tobias B, Burlingame Alma L, Liu Zhandong, Rasband Matthew N, Zoghbi Huda Y

Abstract excerpt

MeCP2 is associated with Rett syndrome (RTT), MECP2 duplication syndrome, and a number of conditions with isolated features of these diseases, including autism, intellectual disability, and motor dysfunction. MeCP2 is known to broadly bind methylated DNA, but the precise molecular mechanism driving disease pathogenesis remains to be determined. Using proximity-dependent biotinylation (BioID), we identified a...

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Identifiers

PMID: 35074918
DOI: 10.1073/pnas.2119078119
PMCID: PMC8794850

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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