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Article

Uncovering Molecular Mechanisms of Drug Resistance via Network-Constrained Common Structure Identification.

Journal of computational biology : a journal of computational molecular cell biology - 1 Mar 2022

Park Heewon, Yamaguchi Rui, Imoto Seiya, Miyano Satoru

Abstract excerpt

Uncovering mechanisms of acquired drug resistance has garnered increasing attention worldwide as drug resistance reduces antibiotic and chemotherapy effectiveness. Most bioinformatics studies have elucidated these mechanisms based on differentially expressed gene (DEG) analysis. However, considering the associated complex network of biological systems, the specific molecular interactions must also be studied to...

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Identifiers

PMID: 35073162
DOI: 10.1089/cmb.2021.0314

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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