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DRdriver: identifying drug resistance driver genes using individual-specific gene regulatory network.

Briefings in bioinformatics - 19 Mar 2023

Huang Yu-E, Zhou Shunheng, Liu Haizhou, Zhou Xu, Yuan Mengqin, Hou Fei, Chen Sina, Chen Jiahao, Wang Lihong, Jiang Wei

Abstract excerpt

Drug resistance is one of principal limiting factors for cancer treatment. Several mechanisms, especially mutation, have been validated to implicate in drug resistance. In addition, drug resistance is heterogeneous, which makes an urgent need to explore the personalized driver genes of drug resistance. Here, we proposed an approach DRdriver to identify drug resistance driver genes in individual-specific network...

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PMID: 36869849
DOI: 10.1093/bib/bbad066

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