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Cells Overexpressing ALS-Associated SOD1 Variants Are Differentially Susceptible to CuATSM-Associated Toxicity.

ACS chemical neuroscience - 17 Aug 2022

Brown Mikayla L, McAlary Luke, Lum Jeremy S, Farrawell Natalie E, Yerbury Justin J

Abstract excerpt

CuATSM has repeatedly demonstrated to be therapeutically effective in SOD1 mouse models of amyotrophic lateral sclerosis (ALS), leading to current clinical trials. CuATSM acts to stabilize ALS-associated mutant SOD1 protein by supplying copper. However, in vitro work has demonstrated that CuATSM is only therapeutic for wild-type-like SOD1 mutants, not metal-binding-region mutants, suggesting that CuATSM may have...

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PMID: 35900338
DOI: 10.1021/acschemneuro.2c00253

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