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Article

Maternal P2X7 receptor inhibition prevents autism-like phenotype in male mouse offspring through the NLRP3-IL-1β pathway.

Brain, behavior, and immunity - 1 Mar 2022

Szabó Dorottya, Tod Pál, Gölöncsér Flóra, Román Viktor, Lendvai Balázs, Otrokocsi Lilla, Sperlágh Beáta

Abstract excerpt

Autism spectrum disorder (ASD) is a complex neurodevelopmental condition caused by interactions of environmental and genetic factors. Recently we showed that activation of the purinergic P2X7 receptors is necessary and sufficient to convert maternal immune activation (MIA) to ASD-like features in male offspring mice. Our aim was to further substantiate these findings and identify downstream signaling pathways...

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Source

Identifiers

PMID: 35065198
DOI: 10.1016/j.bbi.2022.01.015

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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