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Article

Bacterial-induced maternal interleukin-17A pathway promotes autistic-like behaviors in mouse offspring

1 Jan 2020

Abstract excerpt

Maternal immune activation (MIA) by an infection is considered to be an important environmental factor of fetal brain development. Recent animal model on MIA induced by polyinosinic:polycytidylic acid, a mimic of viral infection, demonstrates that maternal IL-17A signaling is required for the development of autism spectrum disorder (ASD)-like behaviors of offspring. However, there is little information on...

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PMID: 32009087
DOI: 10.1538/expanim.19-0156

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