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Article

A deterministic, c-di-GMP-dependent program ensures the generation of phenotypically similar, symmetric daughter cells during cytokinesis.

Nature communications - 17 Jul 2024

Pérez-Burgos María, Herfurth Marco, Kaczmarczyk Andreas, Harms Andrea, Huber Katrin, Jenal Urs, Glatter Timo, Søgaard-Andersen Lotte

Abstract excerpt

Phenotypic heterogeneity in bacteria can result from stochastic processes or deterministic programs. The deterministic programs often involve the versatile second messenger c-di-GMP, and give rise to daughter cells with different c-di-GMP levels by deploying c-di-GMP metabolizing enzymes asymmetrically during cell division. By contrast, less is known about how phenotypic heterogeneity is kept to a minimum. Here,...

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Identifiers

PMID: 39019889
DOI: 10.1038/s41467-024-50444-4
PMCID: PMC11255338

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