Article
Night Shift Work, MTNR1B rs10830963 Polymorphism, and Prostate Cancer Risk: Findings from a Prospective, Population-Based Study.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Apr 2022
Yang Lulu, Chen Jie, Feng Hongliang, Ai Sizhi, Liu Yue, Chen Xinru, Lei Binbin, Chan Joey W Y, Chau Steven Wai Ho, Tse Lap Ah, Ho Amy Wing-Yin, Ho Chung Shun, Wing Yun Kwok, Zhang Jihui
Abstract excerpt
BACKGROUND: The association between night shift work and prostate cancer is controversial. Evidence shows that genetic and environmental factors both contribute to the development of prostate cancer. It is well known that melatonin plays a protective role in prostate cancer. Melatonin receptor 1B gene (MTNR1B) rs10830963 influences the dynamics of melatonin secretion, and night shift work, which disrupts our...
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