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Article

Multimodal MRI features predict isocitrate dehydrogenase genotype in high-grade gliomas.

Neuro-oncology - 1 Jan 2017

Zhang Biqi, Chang Ken, Ramkissoon Shakti, Tanguturi Shyam, Bi Wenya Linda, Reardon David A, Ligon Keith L, Alexander Brian M, Wen Patrick Y, Huang Raymond Y

Abstract excerpt

BACKGROUND: High-grade gliomas with mutations in the isocitrate dehydrogenase (IDH) gene family confer longer overall survival relative to their IDH-wild-type counterparts. Accurate determination of the IDH genotype preoperatively may have both prognostic and diagnostic value. The current study used a machine-learning algorithm to generate a model predictive of IDH genotype in high-grade gliomas based on clinical...

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Source

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Identifiers

PMID: 27353503
DOI: 10.1093/neuonc/now121
PMCID: PMC5193019

Genes

IDH1
IDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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