Article
Morning Cortisol and Circulating Inflammatory Cytokine Levels: A Mendelian Randomisation Study.
Genes - 8 Jan 2022
Rajasundaram Skanda, Rahman Rezbieara P, Woolf Benjamin, Zhao Sizheng Steven, Gill Dipender
Abstract excerpt
Cortisol exerts a broad anti-inflammatory effect on the immune system. Inflammatory cytokines contribute to the molecular signalling pathways implicated in various autoimmune and inflammatory conditions. However, the mechanisms by which cortisol modulates such signalling pathways remain uncertain. Leveraging summary-level data from the CORtisol NETwork (CORNET, n = 25,314) and FINRISK (n = 8293) genome-wide...
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