Article
Structure-function study of cathelicidin-derived bovine antimicrobial peptide BMAP-28: design of its cell-selective analogs by amino acid substitutions in the heptad repeat sequences.
Biochimica et biophysica acta - 1 Nov 2009
Ahmad Aqeel, Asthana Neeta, Azmi Sarfuddin, Srivastava Raghvendra M, Pandey Brijesh K, Yadav Vikas, Ghosh Jimut Kanti
Abstract excerpt
Although BMAP-28 is a potent cathelicidin-derived bovine antimicrobial peptide, its cytotoxic activity against the human and other mammalian cells is of concern for converting it into a novel antimicrobial drug. We have identified a short leucine and isoleucine zipper sequences at the N- and C-terminals of BMAP-28, respectively. To understand the possible role of these structural elements in BMAP-28, a number of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.