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Article

MicroRNA-1287-5p promotes ferroptosis of osteosarcoma cells through inhibiting GPX4

2 Dec 2021

Abstract excerpt

Osteosarcoma is the most prevalent primary bone malignancy in adolescents, and ferroptosis is implicated in its pathogenesis. MicroRNA (miR)-1287-5p plays critical roles in multiple human cancers, and the present study aims to investigate the role and underlying mechanisms of miR-1287-5p in regulating ferroptosis and osteosarcoma progression. Human osteosarcoma cell lines were treated with the mimic, inhibitor or...

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PMID: 35038953
DOI: 10.1080/10715762.2021.2024816

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