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Article

HOTTIP suppresses ferroptosis via mediating DGCR8/miR‑214‑3p/GPX4 regulatory axis in osteosarcoma

13 Jun 2025

Abstract excerpt

Osteosarcoma (OS) is the most common primary bone malignancy in children and adolescents and the current typical strategy remains unsatisfactory in clinical practice. Ferroptosis has been considered as a novel form of programmed cell death in eukaryotic cells, which is characterized by iron‑dependent lipid peroxidation accumulation. The emergence of ferroptosis brings great hope to develop the potential...

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PMID: 40539448
DOI: 10.3892/or.2025.8927

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