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CAFs exosomal miR-21-5p suppresses ferroptosis and promotes proliferation and migration in osteosarcoma

19 Aug 2025

Abstract excerpt

BACKGROUND: Osteosarcoma is one of the malignant tumors in children and adolescents patients. Uncontrolled and unlimited proliferation and metastasis lead to poor overall survival. CAFs play a pivotal role in the osteosarcoma tumor microenvironment, exerting significant influence on prognosis and treatment outcomes. However, there remains a need for further exploration into the intricate molecular mechanisms...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40826086
DOI: 10.1186/s12935-025-03930-8

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