Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

GPX4 Regulates Tumor Cell ProliferationviaSuppressing Ferroptosis and Exhibits Prognostic Significance in Gastric Cancer

1 Dec 2022

Abstract excerpt

BACKGROUND/AIM: Gastric cancer (GC) is the fourth leading cause of cancer-related death worldwide. Glutathione peroxidase 4 (GPX4) is a glutathione-dependent antioxidant enzyme known to regulate ferroptosis, which is a non-apoptotic form of cell death accompanied by iron-dependent accumulation of reactive oxygen species (ROS). This study evaluated the expression and function of GPX4 in GC. MATERIALS AND METHODS:...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Ferroptosis and cancer prognosis
Share to Selenium in Biological Systems
Share to Trace Elements in Health

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36456115
DOI: 10.21873/anticanres.16079

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

GPX4 Regulates Tumor Cell ProliferationviaSuppressing Ferroptosis and Exhibits Prognostic Significance in Gastric CancerPMID 36456115Read ↗

Inhibition of tumor propellant glutathione peroxidase 4 induces ferroptosis in cancer cells and enhances anticancer effect of cisplatinSemantic proximity Read ↗

Pan-Cancer Analysis of the Role of the Ferroptosis-Related Biomarker GPX4: A Potential Target for Prognosis and ImmunotherapySemantic proximity Read ↗

Cysteine Dioxygenase 1 Mediates Erastin-Induced Ferroptosis in Human Gastric Cancer CellsSemantic proximity Read ↗

Glutathione peroxidase 7 suppresses cancer cell growth and is hypermethylated in gastric cancerSemantic proximity Read ↗

Targeting ferroptosis in gastric cancer: Strategies and opportunitiesSemantic proximity Read ↗

Increased expression of GPX4 promotes the tumorigenesis of thyroid cancer by inhibiting ferroptosis and predicts poor clinical outcomesSemantic proximity Read ↗

GPX7 Is Targeted by miR-29b and GPX7 Knockdown Enhances Ferroptosis Induced by Erastin in GliomaSemantic proximity Read ↗

Enforced miR-144-5p Expression Sensitizes Erastin-Induced Ferroptosis via Targeting Nrf2 in Gastric Cancer CellsSemantic proximity Read ↗

Prospects for Anti-Tumor Mechanism and Potential Clinical Application Based on Glutathione Peroxidase 4 Mediated FerroptosisSemantic proximity Read ↗

Targeting GPX4 in human cancer: Implications of ferroptosis induction for tackling cancer resilienceSemantic proximity Read ↗

Identification of GPX4 as a therapeutic target for lung adenocarcinoma after EGFR-TKI resistanceSemantic proximity Read ↗

GPX4, ferroptosis, and diseasesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.