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Article

HPV51-associated Leiomyosarcoma

16 Jan 2022

Abstract excerpt

Inactivating mutations in tumor suppressor genes TP53 and RB1 are considered central drivers in leiomyosarcomas (LMSs). In high-risk human papillomavirus (HPV)-related tumors, a similar functional outcome is achieved through oncoproteins E6 and E7, which inactivate the p53 and RB1 proteins, respectively. Here, we hypothesized that HPV infection could provide an alternative mechanism for tumorigenesis in a subset...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 35034043
DOI: 10.1097/pas.0000000000001862

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