Article
Mutant B-Raf Kinase Inhibitors as Anticancer Agents.
Anti-cancer agents in medicinal chemistry - 1 Jan 2016
Asati Vivek, Bharti Sanjay K, Mahapatra Debarshi K
Abstract excerpt
The Ras/Raf/MEK/ERK signaling pathway involves various kinases in which each kinase is associated with one another through signals and regulates cell proliferation, differentiation and apoptosis. This pathway is dysregulated almost in all cancers due to the amplification and genetic mutation of various components of the pathway. The genetic mutations have been reported to cause drug resistance to the current...
Topics
- Antineoplastic Agents
- Drug Screening Assays, Antitumor
- Humans
- Mutation
- Neoplasms
- Protein Kinase Inhibitors
- Proto-Oncogene Proteins B-raf