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Article

A Progressive Review of V600E-B-RAF-Dependent Melanoma and Drugs Inhibiting It.

Mini reviews in medicinal chemistry - 1 Jan 2017

Khan Mohammad Ashrafuddin, El-Gamal Mohammed I, Oh Chang-Hyun

Abstract excerpt

B-RAF gene is a component of the MAPK pathway that plays a very important role in cell division, survival, proliferation, and many other cellular functions. Mutations of the B-RAF (such as V600E-B-RAF) lead to melanoma, which is one of the leading causes of death worldwide. R&D progress is being done aiming at improved therapy in the future. The existing melanoma therapy is left out with poor overall...

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Identifiers

PMID: 27337967
DOI: 10.2174/1389557516666160622213142

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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