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Article

Pharmacological fatty acid synthase inhibitors differently affect the malignant phenotype of oral cancer cells.

Archives of oral biology - 1 Mar 2022

Boelcke Willian Peter, Teixeira Isadora Ferrari, Aquino Iara Gonçalves, Mazzaro Amanda Ramos, Cuadra-Zelaya Florence Juana Maria, de Souza Ana Paula, Salo Tuula, Della Coletta Ricardo, Graner Edgard, Bastos Débora Campanella

Abstract excerpt

OBJECTIVE: Fatty acid synthase levels are associated with aggressiveness, prognosis, and risk of metastasis in oral squamous cell carcinomas. This enzyme contains seven catalytic domains and its inhibition by synthetic or natural drugs has antineoplastic properties such as C75, which is a synthetic inhibitor of the β- ketoacyl synthase domain, the antibiotic triclosan, ligand of the enoyl reductase domain, and...

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PMID: 35026648
DOI: 10.1016/j.archoralbio.2021.105343

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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