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iWhale: a computational pipeline based on Docker and SCons for detection and annotation of somatic variants in cancer WES data.

Briefings in bioinformatics - 20 May 2021

Binatti Andrea, Bresolin Silvia, Bortoluzzi Stefania, Coppe Alessandro

Abstract excerpt

Whole exome sequencing (WES) is a powerful approach for discovering sequence variants in cancer cells but its time effectiveness is limited by the complexity and issues of WES data analysis. Here we present iWhale, a customizable pipeline based on Docker and SCons, reliably detecting somatic variants by three complementary callers (MuTect2, Strelka2 and VarScan2). The results are combined to obtain a single...

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PMID: 32436933
DOI: 10.1093/bib/bbaa065
PMCID: PMC8557746

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