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Article

Single-gene long-read sequencing illuminates Escherichia coli strain dynamics in the human intestinal microbiome.

Cell reports - 11 Jan 2022

Hu Dalong, Fuller Nicholas R, Caterson Ian D, Holmes Andrew J, Reeves Peter R

Abstract excerpt

Gut microbiome is of major interest due to its close relationship to health and disease. Bacteria usually vary in gene content, leading to functional variations within species, so resolution higher than species-level methods is needed for ecological and clinical relevance. We design a protocol to identify strains in selected species with high discrimination and in high numbers by amplicon sequencing of the...

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Identifiers

PMID: 35021078
DOI: 10.1016/j.celrep.2021.110239

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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