Article

Revealing within-species diversity in uncultured human gut bacteria with single-cell long-read sequencing

2022-03-24

Abstract excerpt

Bacterial genome structure changes dynamically, and structural variants can change bacterial phenotype; However, obtaining the complete genome and analyzing genome structure of uncultured bacteria has been challenging. We aimed to develop a single-cell amplified genome long-read assembly (scALA) workflow to construct circular single-cell amplified genomes (cSAGs) from long-read single-cell sequencing data of targe...

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Literature Corpus work: 573ccfca-092d-5c21-b4b1-c6bc9a934134
DOI: 10.1101/2022.03.24.485581

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