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Dynamics of trophoblast differentiation in peri-implantation–stage human embryos

21 Oct 2019

Abstract excerpt

Single-cell RNA sequencing of cells from cultured human blastocysts has enabled us to define the transcriptomic landscape of placental trophoblast (TB) that surrounds the epiblast and associated embryonic tissues during the enigmatic day 8 (D8) to D12 peri-implantation period before the villous placenta forms. We analyzed the transcriptomes of 3 early placental cell types, cytoTB (CTB), syncytioTB (STB), and...

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PMID: 31636193
DOI: 10.1073/pnas.1911362116

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