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Article

Chronic β2AR stimulation limits CFTR activation in human airway epithelia.

JCI insight - 22 Feb 2018

Brewington John J, Backstrom Jessica, Feldman Amanda, Kramer Elizabeth L, Moncivaiz Jessica D, Ostmann Alicia J, Zhu Xiaoting, Lu L Jason, Clancy John P

Abstract excerpt

Traditional pulmonary therapies for cystic fibrosis (CF) target the downstream effects of CF transmembrane conductance regulator (CFTR) dysfunction (the cause of CF). Use of one such therapy, β-adrenergic bronchodilators (such as albuterol), is nearly universal for airway clearance. Conversely, novel modulator therapies restore function to select mutant CFTR proteins, offering a disease-modifying treatment....

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Source

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Identifiers

PMID: 29467332
DOI: 10.1172/jci.insight.93029
PMCID: PMC5916247

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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