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Article

STAT3 Polymorphism Associates With mTOR Inhibitor-Induced Interstitial Lung Disease in Patients With Renal Cell Carcinoma.

Oncology research - 4 May 2022

Yamamoto Kazuhiro, Ioroi Takeshi, Shinomiya Kazuaki, Yoshida Ayaka, Harada Kenichi, Fujisawa Masato, Omura Tomohiro, Ikemi Yasuaki, Nakagawa Shunsaku, Yonezawa Atsushi, Ogawa Osamu, Matsubara Kazuo, Iwamoto Takuya, Nishikawa Kohei, Hayashi Sayaka, Tohara Daichi, Murakami Yoji, Motoshima Takanobu, Jono Hirofumi, Yano Ikuko

Abstract excerpt

We evaluated the association of signal transducer and activator of transcription 3 (STAT3) polymorphisms with the incidence of mammalian target of rapamycin (mTOR) inhibitor-induced interstitial lung disease (ILD) in patients with renal cell carcinoma (RCC). We also used lung-derived cell lines to investigate the mechanisms of this association. Japanese patients with metastatic RCC who were treated with mTOR...

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Share to Carcinoma, Renal Cell
Share to Kidney Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lung Diseases, Interstitial

Share to Polymorphism, Single Nucleotide

Share to STAT3 Transcription Factor

Share to TOR Serine-Threonine Kinases

Source

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Identifiers

PMID: 35016744
DOI: 10.3727/096504022X16418911579334
PMCID: PMC9110706

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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