Linking prolonged childhood and adolescent loneliness to schizophrenia spectrum disorders: results from EU-GEI study.

doi:10.1192/bjp.2025.100

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Article

Linking prolonged childhood and adolescent loneliness to schizophrenia spectrum disorders: results from EU-GEI study.

The British journal of psychiatry : the journal of mental science - 1 May 2026

Andreu-Bernabeu Álvaro, González-Peñas Javier, Mora Alberto, Bernardo Miguel, Mezquida Gisela, Amoretti Silvia, Bobes Julio, Saiz Pilar A, García-Portilla Maria Paz, Sanjuan Julio, Santos José Luis, Jiménez-López Estela, Arrojo Manuel, Carracedo Angel, Parellada Mara, Maric Nadja P, Atbaşoğlu Cem, Üçok Alp, Alptekin Köksal, Saka Meram Can, Pries Lotta-Katrin, O'Donovan Michael, van Os Jim, Rutten Bart P F, Delespaul Philippe, Guloksuz Sinan, Arango Celso, Díaz-Caneja Covadonga M

Abstract excerpt

BACKGROUND: Prolonged childhood and adolescent loneliness (CAL) is linked to various adverse mental health outcomes, yet its impact on schizophrenia spectrum disorders (SSD) has been understudied. While loneliness is associated with psychosis and worsens symptoms in SSD, few studies have explored the long-term effects of early loneliness on SSD risk. Understanding how CAL interacts with genetic liability to...

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PMID: 40519115
DOI: 10.1192/bjp.2025.100

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