Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genome-Wide Association Study of Loneliness Demonstrates a Role for Common Variation.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Mar 2017

Gao Jianjun, Davis Lea K, Hart Amy B, Sanchez-Roige Sandra, Han Lide, Cacioppo John T, Palmer Abraham A

Abstract excerpt

Loneliness is a complex biological trait that has been associated with numerous negative health outcomes. The measurement and environmental determinants of loneliness are well understood, but its genetic basis is not. Previous studies have estimated the heritability of loneliness between 37 and 55% using twins and family-based approaches, and have explored the role of specific candidate genes. We used genotypic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Depression

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CHRNA4 gene

Share to RORA gene

Share to Genome-Wide Association Study

Share to Mental Disorders

Share to Neuroticism

Share to Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 27629369
DOI: 10.1038/npp.2016.197
PMCID: PMC5312064

Genes

APOE
BDNF
CHRNA4
CRHR1
DRD2
GRM8
MTHFR
OXTR
RORA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genome-Wide Association Study of Loneliness Demonstrates a Role for Common Variation.PMID 27629369Read ↗

Phenome-wide Investigation of Health Outcomes Associated with Genetic Predisposition to LonelinessSemantic proximity Read ↗

Prominent health problems, socioeconomic deprivation, and higher brain age in lonely and isolated individuals: A population-based studySemantic proximity Read ↗

Genetic risk for major depressive disorder and loneliness in gender-specific associations with coronary artery diseaseSemantic proximity Read ↗

Elucidating the genetic basis of social interaction and isolation.Semantic proximity Read ↗

Associations of social isolation and loneliness with neurological disorders, psychiatric disorders, brain structures and behavioural phenotypes among UK Biobank participants.Semantic proximity Read ↗

Predicting loneliness with polygenic scores of social, psychological and psychiatric traits.Semantic proximity Read ↗

Polygenic overlap and shared genetic loci between loneliness, severe mental disorders, and cardiovascular disease risk factors suggest shared molecular mechanisms.Semantic proximity Read ↗

Understanding the relationship between loneliness, substance use traits and psychiatric disorders: A genetically informed approach.Semantic proximity Read ↗

Influence of social environment on loneliness in older adults: Moderation by polymorphism in the CRHR1.Semantic proximity Read ↗

Genetic risk for major depressive disorder and loneliness in sex-specific associations with coronary artery disease.Semantic proximity Read ↗

Polygenic contribution to the relationship of loneliness and social isolation with schizophrenia.Semantic proximity Read ↗

Connecting loneliness with pathological personality traits: Evidence for genetic and environmental mediation from a study of older twins.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.