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Article

Polygenic risk of social isolation behavior and its influence on psychopathology and personality.

Molecular psychiatry - 1 Nov 2024

Socrates Adam J, Mullins Niamh, Gur Ruben C, Gur Raquel E, Stahl Eli, O'Reilly Paul F, Reichenberg Abraham, Jones Hannah, Zammit Stanley, Velthorst Eva

Abstract excerpt

Social isolation has been linked to a range of psychiatric issues, but the behavioral component that drives it is not well understood. Here, a genome-wide associations study (GWAS) was carried out to identify genetic variants that contribute specifically to social isolation behavior (SIB) in up to 449,609 participants from the UK Biobank. 17 loci were identified at genome-wide significance, contributing to a 4%...

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Identifiers

PMID: 38811692
DOI: 10.1038/s41380-024-02617-2
PMCID: PMC11541194

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