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Cancer-Homing CAR-T Cells and Endogenous Immune Population Dynamics

30 Dec 2021

Abstract excerpt

Chimeric antigen receptor (CAR) therapy is based on patient blood-derived T cells and natural killer cells, which are engineered in vitro to recognize a target antigen in cancer cells. Most CAR-T recognize target antigens through immunoglobulin antigen-binding regions. Hence, CAR-T cells do not require the major histocompatibility complex presentation of a target peptide. CAR-T therapy has been tremendously...

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PMID: 35008832
DOI: 10.3390/ijms23010405

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