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Article

Understanding T cell phenotype for the design of effective chimeric antigen receptor T cell therapies.

Journal for immunotherapy of cancer - 1 May 2021

Tantalo Daniela Gm, Oliver Amanda J, von Scheidt Bianca, Harrison Aaron J, Mueller Scott N, Kershaw Michael H, Slaney Clare Y

Abstract excerpt

Rapid advances in immunotherapy have identified adoptive cell transfer as one of the most promising approaches for the treatment of cancers. Large numbers of cancer reactive T lymphocytes can be generated ex vivo from patient blood by genetic modification to express chimeric antigen receptors (CAR) specific for tumor-associated antigens. CAR T cells can respond strongly against cancer cells, and adoptive...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34035114
DOI: 10.1136/jitc-2021-002555
PMCID: PMC8154965

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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