A cross-talk between CAR T cell subsets and the tumor microenvironment is essential for sustained cytotoxic activity

Abstract excerpt

CAR T cells were more efficient at host immune activation but less capable of direct tumor killing. In summary, CAR T cells do not act independently in vivo but rely instead on cytokine-mediated cross-talk with the TME for optimal activity. Invigorating CAR T cell interplay with the host represents an attractive strategy to prevent relapses after therapy.

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